Allison received her B.S. degree in chemistry in 2017 from Saginaw Valley State University (SVSU). At SVSU she studied E. coli contamination and water quality in the Saginaw Bay and surrounding watershed with Dr. David Karpovich. In this same time, she worked for The Dow Chemical Company as a college co-op from 2012 to 2018. At Dow her research focused on the development and optimization of functionalized silicone formulations and the testing of their applications for the global launches of new products. Outside of the lab, Allison enjoys spending time with family and friends, weightlifting, and baking.
Since joining the Tepe lab in the fall of 2018, her research has drawn her into both the synthetic and biological avenues of the Tepe lab research. She is currently working to design and synthesize novel 20S proteasome activators, and then evaluates the biological activity of the analogues synthesized for their ability to activate the 20S proteasome and enhance the rate of degradation of a class of proteins known as intrinsically disordered proteins. This class of proteins has been associated with the progression of a number of neurodegenerative diseases such as Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease, and it is currently being explored if targeting them through 20S-mediated degradation may offer a novel therapeutic for neurodegenerative diseases.
Njomen, Evert; Lansdell, Theresa A.; Vanecek, A.; Benham, Vanessa; Bernard, Matt P.; Yang, Ya-Ting; Schall, Peter Z.; Isaac, Daniel; Omar Alkharabsheh; Al-Janadi Anas; Giletto, Matthew B.; Ellsworth, Edmund; Taylor, Catherine; Tang, Terence; Lau, Sarah; Bailie, Marc, Bernard; Jamie J.; Yuzbasiyan-Gurkan, Vilma and Tepe, Jetze J. 20S proteasome enhancement targets c-MYC and induces in vivo anti-tumor efficacy, BioRxiv, 2020, https://doi.org/10.1101/2020.08.24.265470
Follow us on Twitter: https://twitter.com/Tepe_Lab
Thank you Taylor, Sophie and Allison of all your hard work in helping me put this together and for the data needed to get his funded!
Rahman was selected as one of the five faculty members from Pakistan's leading research intensive university, LUMS, to receive this award. Rahman is currently an Associate Professor at LUMS after getting his PhD from the Tepe lab at MSU in 2011.
Congrats from all of us!
Biomedicines 2022, 10, 938. https://doi.org/10.3390/biomedicines10050938
Title: Small molecule 20S proteasome enhancer regulates MYC protein stability and exhibits antitumor activity in multiple myeloma.