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Tepe Research Group

Jetze J. Tepe, Ph.D.Photo of Jetze Tepe.

Professor of Chemistry  
Department of Chemistry  
Michigan State University  
East Lansing, MI 48824  
Tel: 517-353-0497  

tepe@chemistry.msu.edu

Ph.D., University of Virginia, 1997 

Post-doctoral, Colorado State University, 2000

Total Synthesis of Natural Products
Marine sponge metabolites represent a highly diverse and structurally complex natural library of compounds with remarkable biological and medicinal properties. Students in the group will develop novel heterocyclic methodologies that enable the efficient synthesis of natural products.

Chemical Biology
The structural diversity of marine sponge metabolites makes them ideal as tools to discover novel targets and mechanisms. The main cellular target of interest is the "proteasome". In our chemical biology lab, students will unravel the biological properties of marine sponge metabolites and determine their use as therapeutic leads or biochemical tools.

Medicinal Chemistry
Our lab develops new chemical methodologies to mimic the diverse structural features found in natural products with the goal to capture their unique biological properties in drug-like scaffolds. Students in the lab with synthesize and test the new scaffolds to optimize the natural product mimics for potency, target selectivity, ADME, PK and PD properties. Current programs are focused on novel therapeutics for multiple myeloma, neurodegenerative diseases, and tuberculosis.

Photo of Twitter logo.  Follow us on Twitter: https://twitter.com/Tepe_Lab

Latest News

May 23, 2022 Very grateful for the NIH's continued support of our work and the funding of our new grant!

Thank you Taylor, Sophie and Allison of all your hard work in helping me put this together and for the data needed to get his funded!

May 22, 2022 Congrats to Rahman Saleem, who was awarded the Vice Chancellors Award for Teaching Excellence at LUMS!

Rahman was selected as one of the five faculty members from Pakistan's leading research intensive university, LUMS, to receive this award. Rahman is currently an Associate Professor at LUMS after getting his PhD from the Tepe lab at MSU in 2011.

Congrats from all of us!

April 19, 2022 Congrats Evert and Allison on your new publication in Biomedicine! Great work.

 Biomedicines 2022, 10, 938. https://doi.org/10.3390/biomedicines10050938

Title: Small molecule 20S proteasome enhancer regulates MYC protein stability and exhibits antitumor activity in multiple myeloma.

April 18, 2022 ...and a big congrats also to Sophie and Corey for their new article in the Journal of Medicinal Chemistry!

Journal of Medicine Chemistry 2022, in print.

Title: "Design, Synthesis and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-synucleinopathies"

More News