Prof. Liangliang Sun Lands NSF Early CAREER Award

  • Oct 4, 2019
  • Liangliang Sun
Prof. Liangliang Sun
Prof. Liangliang Sun

Prof. Liangliang Sun in the Department of Chemistry has received an Early Career Award from the National Science Foundation (NSF) for more than $670,000 for five years to develop a novel mass spectrometry (MS)-based analytical method to identify and to quantify protein molecules that cannot currently be detected in biological samples.

Prof. Sun and his graduate students will develop a new analytical technique to improve the sensitivity of proteomics by at least 100 times, in part by developing novel high-capacity separation platforms, and by improving the technique for interfacing capillary electrophoresis to MS. This high-sensitivity MS-based analytical method will advance fundamental research involving mass-limited protein analyses in many areas, such as developmental biology, cancer biology, and neuroscience. They will then advance the research on embryogenesis with the technology using zebrafish as a model organism to determine the expression dynamics of chromatin-associated proteins in zebrafish embryos during the maternal-to-zygotic transition. They will build the first and largest quantitative proteomic dataset of chromatin-associated proteins in vertebrate embryos. Finally, the project will provide a great opportunity to train our new generation of graduate students for multidisciplinary scientific research. It also will improve students’ education and lab experiences, giving the next generation a better understanding of laboratory research during their undergraduate and even high school years.