Prof. Liangliang Sun Lands NSF Early CAREER Award
- Oct 4, 2019
- Liangliang Sun
Prof. Liangliang Sun in the Department of Chemistry has received an Early Career Award from the National Science Foundation (NSF) for more than $670,000 for five years to develop a novel mass spectrometry (MS)-based analytical method to identify and to quantify protein molecules that cannot currently be detected in biological samples.
Prof. Sun and his graduate students will develop a new analytical technique to improve the sensitivity of proteomics by at least 100 times, in part by developing novel high-capacity separation platforms, and by improving the technique for interfacing capillary electrophoresis to MS. This high-sensitivity MS-based analytical method will advance fundamental research involving mass-limited protein analyses in many areas, such as developmental biology, cancer biology, and neuroscience. They will then advance the research on embryogenesis with the technology using zebrafish as a model organism to determine the expression dynamics of chromatin-associated proteins in zebrafish embryos during the maternal-to-zygotic transition. They will build the first and largest quantitative proteomic dataset of chromatin-associated proteins in vertebrate embryos. Finally, the project will provide a great opportunity to train our new generation of graduate students for multidisciplinary scientific research. It also will improve students’ education and lab experiences, giving the next generation a better understanding of laboratory research during their undergraduate and even high school years.