Jian Hu helps discover a new Ni(II)-containing cofactor

  • Jul 15, 2015
  • Jian Hu

In the study of a nickel-dependent enzyme, LarA, which catalyzes interconversion of the D- and L-isomers of lactic acid, a research team led by Dr. Robert Hausinger from MMG & BMB, working with Dr. Jian Hu from BMB & Chemistry, discovered a new Ni(II)-containing cofactor using a combination of mass spectrometry, metabolic labeling and x-ray crystallography.  This is the first pincer complex identified in a biological system, which has broad implications on chemistry.  Read the story for more details.