Topic: Glycosciences: From Synthetic Methods to Glycobiology
Speaker: Professor Xue-Wei Liu - Nanyang Technological University, Singapore
Host: Professor Xuefei Huang
Date: Thursday, September 21, 2017
Time: 4:10 PM
Location: 136 CEM
The diverse presence as well as their very specific bio-responses of glycoconjugates found in all living species requires scientists to synthesize and display the precise structure of these complex oligosaccharides and glycoconjugates for various studies in glycosciences. Multitudinous approaches to make glycosidic bonds in a highly stereoselective manner have speedingly emerged for the last two decades. Nonetheless, an efficient and universal method to confidently synthesize various glycoconjugates have yet been established, especially one that is applicable for large scale and structural diversity.
This lecture will present our recent advances in carbohydrate chemistry and glycobiology with emphasis on conceptually new strategies and tactics to illustrate our contribution to this field. Specifically, I will talk on the acceptor-controlled glycosylation and protection-less glycosylation for oligosaccharide synthesis, and dual native chemical ligation (dNCL) for glycoprotein synthesis. I will also present to you an easy access to peptidoglycans, which are used for metabolic labeling of bacteria.