Topic: Activity Based Proteomics – Protein Discovery on a Global Scale
Speaker: Dr. Benjamin Cravatt - The Scripps Research Institute
Host: Professor Jetze Tepe
Date: Thursday, October 26, 2017
Time: 4:10 PM
Location: 136 CEM
Advances in DNA sequencing have massively increased our knowledge of the genetic basis of human disease. Nonetheless, many disease-associated genes encode proteins with poorly characterized functions, limiting our ability to translate human genetic information into a mechanistic understanding of disease and strategies for therapeutic intervention. New methods to characterize the function of proteins on a global scale are accordingly needed. With this goal in mind, we have introduced chemical proteomic technologies that profile the functional state of proteins in native biological systems. Prominent among these methods is activity-based protein profiling (ABPP), which utilizes chemical probes to map the activity state of large numbers of proteins in parallel. In the first lecture, I will describe the application of ABPP to discover and functionally annotate proteins in human physiology and disease. In the second lecture, I will also discuss the generation and implementation of advanced ABPP platforms for proteome-wide ligand discovery to discover and advance drugs for the treatment of human disease.