Topic: Ligand scaffolds with boron and phosphorus: synthetic investigations for metallodrug imaging and solvent-free f-element separations
Speaker: Professor Scott Daly - University of Iowa
Host: Professor Selvan Demir
Date: Monday, November 25, 2019
Time: 11:20 AM
Location: 136 CEM
In this talk, I will describe our efforts to use ligands called TBDPhos and phosphinodiboranates to address important challenges in metallodrug development and nuclear waste remediation. TBDPhos is a class of diphosphorus ligands that contain a bridging triaminoborane called 1,8,10,9-triazaboradecalin (TBD). We have shown that the TBD backbone is chemically reactive and can undergo H-X addition (X = F, Cl, OH, and OR) while TBDPhos is bound to different transition metals. I will discuss how changes to the TBDPhos ligand architecture can be used to control this reactivity and show how we are developing water-soluble complexes that can be labeled rapidly with 18F (a common PET imaging isotope) to image anticancer metallodrug candidates in vivo. I will then report how chelating, phosphide-bridged borohydrides called phosphinodiboranates can be used to prepare homoleptic lanthanide and uranium complexes using solvent-free mechanochemical methods. These results represent part of our ongoing research efforts aimed at separating f-elements by exploiting differences in the volatility of lanthanide and actinide complexes.