Topic: Behind the Iron Curtain: Intermediates and Mechanism in Iron-Catalyzed Transformations in Organic Synthesis
Speaker: Professor Michael Neidig - University of Rochester
Host: Professor Aaron Odom
Date: Monday, October 28, 2019
Time: 11:20 AM
Location: 136 CEM
Despite the success of iron-based catalysts for transformations in organic chemistry, including cross-coupling and C-H functionalization reactions, a detailed molecular level understanding of these systems has remained elusive. This limitation is in stark contrast to palladium chemistry, where detailed studies of active catalyst structure and mechanism have provided the foundation for the continued design and development of catalysts with novel and/or improved catalytic performance. The use of an experimental approach combining advanced inorganic spectroscopies (Mössbauer, magnetic circular dichroism, electron paramagnetic resonance), density functional theory studies, synthesis and kinetic analyses enables the direct evaluation of the active iron species in iron catalyzed transformations in organic chemistry, providing a critical mechanistic framework to facilitate and inspire new iron-based methods development. This presentation will focus on our recent studies in organoiron intermediates in cross-coupling in both the presence and absence of supporting ligands, including the effect of the key additive NMP in achieving highly effective cross-coupling with alkyl Grignard reagent. In addition, recent studies on iron-catalyzed hydromagnesiation and C-H functionalization will also be discussed.