Topic: Application of Mass Spectrometry for Structural Biology and for Detecting and Finding Cures to Brain Disorders
Speaker: Professor Joe Loo - UCLA
Host: Professor Liangliang Sun
Date: Friday, September 27, 2019
Time: 12:30 PM
Location: 136 CEM
Mass spectrometry (MS) of proteins and protein assemblies reveals size and binding stoichiometry. But elucidating their structures to understand their function is more challenging. Native MS and native top-down MS, i.e., fragmentation of the gas-phase protein, can be applied to derive structural information for soluble and membrane protein complexes; much of this information can be correlated to the solution-phase structure. We use native MS to investigate the molecular action of compounds that prevent amyloid fibril formation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The role of quantitative liquid chromatography/MS (i.e., proteomics) to discover new protein biomarkers for head trauma, i.e., traumatic brain injury (TBI) and how these markers perform in clinical studies will also be highlighted.