The Bruening Group
Department of Chemistry
Michigan State University
 Ultrathin Films for Separations, Analysis and Catalysis

Brush-Modified Membranes for Protein Purification

Multilayered Polyelectrolyte Membranes

Catalytic Membranes

Membrane-Based Antibody Arrays

On-probe Capture of Phospho-peptides for Mass Spectrometry

Selective Catalysis with Nanoparticles

Anti-bacterial Membranes

SEM Images

Publications

Graduate School at MSU

MSU chemistry

DOE Support

NSF Support

NSF PIRE Support

ACS PRF Support

Who are we?  We're a  research group in the chemistry department at Michigan State University led by Dr. Merlin Bruening.  The group currently consists (summer 2006) of nine graduate students, two undergraduate students, and two postdoctoral associates. 

What do we do?  We develop new thin films for protein purification in porous supports, membrane-based water reclamation, purification for MALDI mass spectrometry, and selective catalysis. In some cases, students spend a month or two in France or Ukraine in collaborative research.    

What tools do we use?  We use surface infrared spectroscopy, field-emission scanning electron microscopy, electrochemistry, mass spectrometry, ellipsometry, nanofiltration, and atomic force microscopy.  Whenever possible we try to exploit characterization techniques that don't require ultrahigh vacuum so we can simulate actual conditions. 

More Information?  Click on any of the links above for other graphics and descriptions.  If you are interested in graduate work in chemistry at Michigan State University, click here.  We also have a list of publications describing prior work.  If you have specific questions, send e-mail to bruening@chemistry.msu.edu
 

The Bruening group  (summer 2006):  From left to right, front:  Malaisamy Ramamoorthy, Jinhua Dai, Srividhya Kidambi, Parul Jain, Somnath Bhattacharjee, Fei Xu, and Lu Ouyang. Not pictured: Elizabeth Igrisen.
back:  Lei Sun, David Dotzauer, Jamie Dunn, Randy Benedict, Maneesha Adusumilli, and Merlin Bruening. 

Schematic diagram of analytes approaching a multilayer polyelectrolyte membrane.  Multilayer membranes can separate monovalent and divalent anions (Cl-/SO42- selectivities as high as 1000) as well as small organic molecules such as glucose and sucrose.  In some cases, we have also separated gases such as O2 and N2.  Because the membranes are ultrathin, they allow high fluxes.